One thing that stood out during the later part of last season about the defense was that they seem to give up quite a few big plays; not sure whether that was directly related to the injuries. Last year's return/punt coverage was also quite subpar in quite a few games.
I would tend to be more concerned about the defense, esp. with the dual coordinators. It would be a real test to see if the defensive scheme works and not getting exploited too much. The talent is all there. I think the offense should be fine.